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Key findings include: Reversal of age-dependent insulin resistance in 18-month-old mice treated with MOTS-c Prevention of high-fat diet-induced obesity and insulin resistance in multiple mouse strains Enhanced insulin-stimulated glucose clearance rates (measured via glucose tolerance testing) Improved skeletal muscle glucose uptake independent of insulin pathway activation Studies using hyperinsulinemic-euglycemic clamp methodology confirmed increased whole-body insulin sensitivity following MOTS-c treatment